Which agent is a nonsedating antihistamine
Elimination of suspected triggers should be advocated.
Avoidance of mental stress, Nocturnal pruritus may be reduced by lukewarm bathing and keeping the ambient temperature of the bedroom cool.
Antihistamines are known to quell inflammation and are common over-the-counter remedies for several dermatologic conditions.
But like many other agents, antihistamines are most effective under a particular set of circumstances.
Specifically, methods of treating acute allergic reactions including anaphylaxis with the compositions are disclosed. Acute allergic reaction including anaphylaxis, is a systemic, immediate hypersensitivity reaction caused by exposure to a specific antigen.
In certain embodiments, the injectable compositions are bioequivalent to currently marketed oral dosage forms. The immune system activates immunoglobulin E (Ig E), which reacts with effector cells (mast cells and basophils).
Given the number of antihistamines available—from prescription to over-the-counter (OTC), sedating to non-sedating— choosing the agent that will provide the best results while carrying the least risk for adverse events is essential.
Adverse events associated with antihistamines tend not to be severe, but it is nonetheless important to minimize them in younger patients.
However, these OTC agents do not appear to be very helpful for eczema/atopic dermatitis, Dr. “Nonsedating antihistamines are mainly only helpful in the facial area if there is a lot of itch and scratching/rubbing due to allergies or hay fever,” she says.
Common gastrointestinal manifestations include nausea, vomiting, abdominal pains or cramps, and diarrhea.
Although symptoms vary between acute allergy patients, onset generally occurs seconds to minutes after exposure to an antigen and requires prompt treatment.
Antihistamines are commonly used to treat several dermatologic conditions, according to Wynnis Tom, MD, Assistant Clinical Professor in the Departments of Pediatrics and Medicine (Dermatology) at the University of California, San Diego.
These include urticaria (hives), atopic dermatitis (AD), facial eczema due to nasal allergies/hay fever, as well as bug bites. Tom observes that in pediatric patients, antihistamines should be chosen so as to minimize potential adverse events, such as drowsiness, which could interfere with school or activities.
The drug is an ingredient in several products sold as sleep aids, either alone or in combination with other ingredients such as acetaminophen (paracetamol). Diphenhydramine can cause minor psychological dependence. Other side effects include motor impairment (ataxia), flushed skin, blurred vision at nearpoint owing to lack of accommodation (cycloplegia), abnormal sensitivity to bright light (photophobia), sedation, difficulty concentrating, short-term memory loss, visual disturbances, irregular breathing, dizziness, irritability, itchy skin, confusion, increased body temperature (in general, in the hands and/or feet), temporary erectile dysfunction, and excitability, and although it can be used to treat nausea, higher doses may cause vomiting.